Sensitivity of tumor motion simulation accuracy to lung biomechanical modeling approaches and parameters

Biomechanical Modeling for Lung Tumor Motion Prediction during Brachytherapy and Radiotherapy

Biomechanical Modeling and Analysis of Human Motion

Human motion is accomplished through muscle actuation producing torque about each joint. Inverse dynamics allows for the measurement of these forces and torques to be determined with non-invasive data collection techniques at low cost. Video was processed using MATLAB to determine position data of markers on each joint throughout a given motion. Position data was then converted into a series of...

Dynamic MLC Tracking Using 4D Lung Tumor Motion Modelling and EPID Feedback

Background: Respiratory motion causes thoracic movement and reduces targeting accuracy in radiotherapy. Objective: This study proposes an approach to generate a model to track lung tumor motion by controlling dynamic multi-leaf collimators. Material and Methods: All slices which contained tumor were contoured in the 4D-CT images for...

Biomechanical Modeling of Tumor Growth: Its Relevance to Glioma Research

In 2009 the US National Center for Health Statistics showed that cancer is close to becoming the deadliest disease of modern times. Recent years have seen unprecedented advancements in medicine that have contributed to a substantial decrease in the death rates of some serious diseases such as heart disease, stroke, influenza and pneumonia. However, with cancer, equivalent scientific and technol...

An overview of therapeutic approaches to brain tumor stem cells

 Primary and secondary malignant central nervous system (CNS) tumors are devastating invasive tumors able to give rise to many kinds of differentiated tumor cells. Glioblastoma multiform (GBM), is the most malignant brain tumor, in which its growth and persistence depend on cancer stem cells with enhanced DNA damage repair program that also induces recurrence and resists current chemo- and radi...